Univariate-Guided Sparse Regression for Biobank-Scale High-Dimensional Omics Data

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High-dimensional regression
penalized regression
We propose a univariate-guided sparse regression framework for efficient analysis of biobank-scale high-dimensional omics data, combining marginal screening with penalized regression.
Authors

Joshua Richland

Tuomo Kiiskinen

William Wang

Sophia Lu

Balasubramanian Narasimhan

Trevor Hastie

Manuel Rivas

Robert Tibshirani

Published

November 28, 2025