Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing Cochlea
genomics
clinical
Wnt proteins direct planar cell polarity in vertebrates, but their roles in the cochlea remain unclear. Ablating Wnt secretion in the cochlear epithelium and periotic mesenchyme shows that epithelial and mesenchymal Wnts together act as global instructive cues directing cochlear outgrowth and hair cell orientation.